home *** CD-ROM | disk | FTP | other *** search
- SCIENCE, Page 61Clues from Transsexual Rats
-
-
-
- In at least one animal, the laboratory rat, nature seems much
- more important than nurture in determining sexual orientation and
- behavior. At the University of California, Los Angeles,
- neuroendocrinologist Roger Gorski is learning exactly what little
- boy rats are made of.
-
- First of all, they need testosterone and plenty of it
- early in life. Gorski and his team have found that if they
- castrate rats just after birth, the animals will exhibit
- behavior typical of a she-rat with the hots: arching their
- backs, flexing their tails and allowing other males to mount
- them. But by injecting these neutered males with testosterone,
- researchers can return them to maleness. However, such "rescues"
- work only during the first five days after birth. At day six,
- the castrates are permanent transsexuals. "If these rats could
- talk," Gorski speculates, "I think they might say, `I'm a
- female. Get me out of this male's body.' "
-
- Even more intriguing, the UCLA researcher has learned that
- sex hormones (or the lack thereof) affect the anatomy of a
- rat's brain. Buried deep beneath the cerebral folds, Gorski
- discovered a part of the brain that appears to be involved in
- regulating sexual behavior and is five times as large in males
- as in females. But without testosterone this specialized region
- shrinks in castrated subjects. "In rats, sexual behavior is
- totally dependent on hormones," concludes Gorski. In humans, he
- allows, things are not nearly so simple.
-
-
-
-
-
-
-
-
-